Steady state mice were categorized as responders and non-responders to melanoma immunotherapy treatment.. Responder and non-responder

Stool samples were collected from steady-state mice and subjected to 16S rRNA sequencing. The mice were then treated with either anti-CTLA-4 or isotype control, after which they were retrospectively categorized as control, responder, or non-responder to the anti-CTLA-4 treatment.

本研究从稳态小鼠中收集粪便样本，并对其开展16S rRNA测序（16S rRNA sequencing）。随后对这些小鼠分别施以抗CTLA-4（anti-CTLA-4）治疗或同型对照（isotype control）处理，之后根据对抗CTLA-4治疗的响应情况，将其回顾性划分为对照组、应答组与无应答组。