CAST RR Interval Sub-Study Database

The Cardiac Arrhythmia Suppression Trial (CAST) was a landmark NHLBI-sponsored study designed to test the hypothesis that the suppression of asymptomatic or mildly symptomatic ventricular premature complexes (PVCs) in survivors of myocardial infarction (MI) would decrease the number of deaths from ventricular arrhythmias and improve survival. Enrollment required an acute MI within the preceding 2 years and 6 or more PVCs per hour during a pre-treatment (qualifying) long-term ECG (Holter) recording. Those subjects enrolled within 90 days of the index MI were required to have left ventricular ejection fractions less than or equal to 55%, while those enrolled after this 90 day window were required to have an ejection fraction less than or equal to 40%. CAST enrolled 3,549 patients in all.

心房颤动抑制试验（CAST）是一项由美国国家心脏、肺和血液研究所（NHLBI）资助的里程碑式研究，旨在验证抑制心肌梗死（MI）幸存者中的无症状或轻度症状性室性早搏（PVCs）能够减少由室性心律失常引起的死亡数量并提高生存率的假设。入组条件要求受试者在过去两年内患有急性MI，并且在治疗前的（资格性）长期心电图（Holter）记录中每小时有6次或更多的PVCs。那些在首次MI后90天内入组的受试者要求左心室射血分数不超过55%，而在此90天窗口之后入组的受试者则要求射血分数不超过40%。CAST共入组了3,549名患者。