Proteomic characterization of primary and brain metastatic lung adenocarcinomas in a well-defined patient cohort

Lung adenocarcinoma (LADC) is the most common subtype of non-small cell lung cancer (NSCLC). One major feature of disease progression is the metastatic spread to the central nervous system (CNS). Treatment regimens for brain metastases are limited, thus distant metastases remain the leading cause of tumour-associated deaths globally. The central aim of this paper was to investigate the differences of LADC and brain metastases with reference to fast and slowly progressing patients. Additionally, we elucidated the differences between patients with single versus multiple brain metastases.

肺腺癌（Lung adenocarcinoma, LADC）是非小细胞肺癌（non-small cell lung cancer, NSCLC）最常见的亚型。疾病进展的主要特征之一是向中枢神经系统（central nervous system, CNS）发生转移扩散。当前针对脑转移瘤（brain metastases）的治疗方案十分有限，因此远处转移仍是全球范围内肿瘤相关死亡的首要诱因。本研究的核心目标是探究快速进展与缓慢进展的肺腺癌及脑转移瘤患者之间的差异；此外，本研究还阐明了单发脑转移瘤与多发脑转移瘤患者之间的区别。