Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014

Background: The purpose of this registry study was to evaluate trends in incidence and survival of laryngeal cancer in the Danish population from 1980 to 2014. Methods: This study includes all patients with laryngeal cancer registered in the Danish Cancer Registry (DCR) in the period 1980–2014. The age-adjusted incidence rate (AAIR) per 100,000 and average annual percent change (AAPC) were calculated. We evaluated the relative survival at five years in relation to gender, anatomical location, year at diagnosis, and histological type. Further, an age-period-cohort (APC) model of incidence was constructed. Results: A total of 8748 patients (82% males) were included. The median age at diagnosis was 60 years, range 18–101 years. The AAIR decreased from 3.6 per 100,000 in 1980 to 2.3 per 100,000 in 2014 with an AAPC of –0.8% (p Conclusions: This nation-wide study reports a significant decrease in the incidence of laryngeal cancer. Glottic cancer had a significantly better survival at five years compared to other locations.背景：本登记研究旨在评估1980年至2014年丹麦人群喉癌的发病率与生存率变化趋势。方法：本研究纳入了1980年至2014年期间丹麦癌症登记处（Danish Cancer Registry, DCR）登记的所有喉癌患者。本研究计算了每10万人的年龄标化发病率（age-adjusted incidence rate, AAIR）与年度平均变化百分比（average annual percent change, AAPC），并分析了患者性别、解剖部位、诊断年份及组织学类型与5年相对生存率的相关性。此外，本研究还构建了发病率的年龄-时期-队列（age-period-cohort, APC）模型。结果：本研究共纳入8748例患者，其中男性占82%。患者诊断时的中位年龄为60岁，年龄范围为18~101岁。年龄标化发病率从1980年的每10万人3.6降至2014年的2.3，年度平均变化百分比为-0.8%（p[原文此处内容不完整]）。结论：这项全国性研究表明，喉癌的发病率呈显著下降趋势。声门型喉癌的5年生存率显著优于其他解剖部位的喉癌。