Sequencing of Oscheius tipulae mutants

Genetic screens in the nematode Caenorhabditis elegans identified EGF and Notch pathways as key for vulval precursor cell fate patterning. The present study highlights both necessity and contingency in forward genetic screens by reporting the molecular identification of mutations affecting vulval induction in another nematode, Oscheius tipulae以秀丽隐杆线虫（Caenorhabditis elegans）为模型的遗传筛选研究，已证实表皮生长因子（EGF）与Notch信号通路是阴门前体细胞命运模式形成的关键调控通路。本研究通过报道另一线虫奥氏尖尾线虫（Oscheius tipulae）中影响阴门诱导的突变的分子鉴定结果，凸显了正向遗传筛选兼具必然性与偶然性的双重特征。