Structural modularity of receptor-binding proteins underlies host-range strategy diversification in Klebsiella pneumoniae phages

Data deposit for: Panicker VR, Smug BJ, Klein-Sousa V, Enright MC, Taylor NMI, Drulis-Kawa Z, Mostowy RJ. "Structural modularity of receptor-binding proteins underlies host-range strategy diversification in Klebsiella pneumoniae phages." bioRxiv 2026. https://doi.org/10.64898/2026.05.12.724579 This archive contains all large binary data files required to reproduce the analyses and figures in the paper above. The associated code is available at: https://github.com/VyshakhRP/RBP-div-hostrange Contents: - 01_raw/02_assemblies/ — Raw lysate assemblies for unpublished Klebsiella pneumoniae phages - 01_raw/03_host_genomes/ — Klebsiella pneumoniae host genome sequences (.fasta) - 01_raw/04_phage_genomes/ — Phage genome sequences (.fasta, .gb) - 02_intermediate/09_af3_predictions/ — AlphaFold 3 structure predictions for all receptor-binding proteins (.cif) - 02_intermediate/14_rbps-ecods/ecod.develop288.domains.txt — ECOD domain database (v20230309, develop288) - 02_intermediate/14_rbps-ecods/ecod.develop288.fasta.txt — ECOD domain FASTA (v20230309, develop288) - 05_output/01_genomes/ — Processed phage genome files - 05_output/03_proteins/ — Protein FASTAs and receptor-binding protein structures Usage: Download the archive, extract it, and place each subdirectory into the corresponding location in the cloned GitHub repository. Full instructions are provided in the repository README under Data Availability. Note: The ECOD database files can alternatively be downloaded directly from http://prodata.swmed.edu/ecod/distributions/ (v20230309 / develop288).数据存档对应以下论文：Panicker VR、Smug BJ、Klein-Sousa V、Enright MC、Taylor NMI、Drulis-Kawa Z、Mostowy RJ。论文题为《肺炎克雷伯菌噬菌体受体结合蛋白的结构模块化是宿主范围策略多样化的基础》，发表于bioRxiv预印本平台2026年，DOI：10.64898/2026.05.12.724579 本存档包含复现上述论文分析与图表所需的全部大型二进制数据文件。配套代码已上传至GitHub仓库：https://github.com/VyshakhRP/RBP-div-hostrange 存档内容： - 01_raw/02_assemblies/：未发表的肺炎克雷伯菌噬菌体的原始裂解液组装文件 - 01_raw/03_host_genomes/：肺炎克雷伯菌宿主基因组序列（.fasta格式） - 01_raw/04_phage_genomes/：噬菌体基因组序列（.fasta、.gb格式） - 02_intermediate/09_af3_predictions/：所有受体结合蛋白的AlphaFold 3结构预测文件（.cif格式） - 02_intermediate/14_rbps-ecods/ecod.develop288.domains.txt：ECOD（Evolutionary Classification of Protein Domains，蛋白质结构域进化分类）数据库（版本v20230309，develop288） - 02_intermediate/14_rbps-ecods/ecod.develop288.fasta.txt：ECOD结构域FASTA文件（版本v20230309，develop288） - 05_output/01_genomes/：处理后的噬菌体基因组文件 - 05_output/03_proteins/：蛋白质FASTA文件与受体结合蛋白结构文件 使用方法：下载本存档并解压，将各子目录放置到克隆的GitHub仓库对应的路径下。完整操作说明详见仓库README文档的"数据可用性"章节。 补充说明：ECOD数据库文件也可直接从http://prodata.swmed.edu/ecod/distributions/ 下载（对应版本v20230309 / develop288）。