<b>Cogan Syndrome Development in post-COVID-19 Patients: A Scoping Review Protocol</b>

Cogan syndrome (CS) is a systemic auto-inflammatory disease affecting both large and small vessels. It is characterized by ocular inflammation, vestibulocochlear impairment, and systemic vasculopathy. Though the exact pathological mechanisms remain unclear, some case-reports underline a post-infectious etiology. Endothelial and vascular inflammation are notoriously consequent to Sars-CoV-2 infection, which is also known to have altered the onset of many autoimmune conditions. There are actually only few confirmed cases regarding CS development after COVID-19, in the so-called post-COVID period. The aim of the current Scoping Review is to establish a systematic search of the main articles, reviews and case reports to collect as many studies as possible to provide the conceptual basis for a link between Sars-CoV-2 infection and the development of Cogan Syndrome.科根综合征（Cogan syndrome, CS）是一种累及大血管与小血管的全身性自身炎症性疾病，其临床特征为眼部炎症、前庭耳蜗功能损害及全身性血管病变。目前其确切病理机制尚未明确，部分病例报告提示其存在感染后病因学关联。已知新型冠状病毒（Sars-CoV-2）感染可引发内皮与血管炎症，且该病毒感染已被证实可改变多种自身免疫性疾病的发病进程。截至目前，在所谓的新冠感染后时期内，确诊为新冠感染后继发科根综合征的病例仍较为罕见。本项范围综述（Scoping Review）旨在通过系统检索相关核心期刊论文、综述及病例报告，尽可能收录相关研究，为阐明新型冠状病毒感染与科根综合征发病之间的潜在关联提供概念层面的依据。