<i>Eigen-R²</i> analysis for dissecting data variation,variable-associated gene identification and functional annotation enrichment.

All the gene lists as well as the corresponding functional annotation enriched terms obtained via DAVID were provided in the Table S3.通过DAVID（Database for Annotation, Visualization and Integrated Discovery）数据库获取的全部基因列表及其对应的功能注释富集术语，均已在补充表S3（Table S3）中提供。