c-Fos bound proximal regions are enriched by CCAAT box motifs.

Proportion of CCAAT box motif occurrence in proximal and distal genomic ChIP-seq intervals bound by c-Fos, but not by NF-YB are shown. Proximal (p) and distal (d) genomic intervals targeted by c-Fos, but not by NF-YB (column c-Fos of Table 1) differ significantly in the occurrence of the CCAAT box motifs detected by an NF-Y PWM (Fig 1); CCAAT+: number of intervals with, CCAAT−: without a detectable CCAAT box motif. In the last column the Fisher’s Exact Odds Ratios (OR, bold) and the corresponding P-values (in parentheses) are given.

本研究展示了仅结合c-Fos而非NF-YB的基因组近端与远端染色质免疫共沉淀测序（ChIP-seq）区间内CCAAT盒基序（CCAAT box motif）的出现比例。仅由c-Fos结合且未被NF-YB结合的近端（标注为p）与远端（标注为d）基因组区间（对应表1的c-Fos列），在经NF-Y位置权重矩阵（Position Weight Matrix，PWM）检测到的CCAAT盒基序出现频率上存在显著差异（见图1）；其中CCAAT+代表携带可检测CCAAT盒基序的区间数目，CCAAT−代表未携带可检测CCAAT盒基序的区间数目。最后一列给出了费希尔精确检验比值比（Odds Ratio，OR，以粗体标注）及其对应的P值（标注于括号内）。