首页/数据集/IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy

IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy

ChEBI2013-08-01 更新2026-07-21 收录

视网膜病变动物模型

神经退行性机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MEXP-3786 数据链接链接失效反馈

官方服务：

资源简介：

IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy

应用场景：

创建时间：

2013-08-01

网络药理学

神经退行性机制

Resveratrol is a natural polyphenol in lots of foods and traditional Chinese medicines, which has shown promising treatment for neurodegenerative diseases (NDs). However, the molecular mechanisms of i

NIAID Data Ecosystem40

Determining transcriptome changes in whole spinal cord of GarsdelETAQ/+ adult onset mice [18-burgess-006]

神经退行性机制

转录组学分析

To determine transcriptome changes in spinal cord induced by the GarsdelETAQ mutation. How mutations in broadly expressed housekeeping genes lead to neurodegeneration in specific cell types remains un

NIAID Data Ecosystem10

The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases V

神经退行性机制

小胶质细胞表型

Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent mol

NIAID Data Ecosystem00

Type I Interferon Signaling Mediates Microglial Dysfunction and Senescence in Human-Mouse Chimeric Brain Models of Down Syndrome and Alzheimer's Disease [single-cell RNA-seq]

神经退行性机制

小胶质细胞衰老

Microglia are critical for brain development and play a central role in Alzheimer's disease (AD) etiology. Down syndrome (DS), also known as trisomy 21, is the most common genetic origin of intellectu

NIAID Data Ecosystem10

APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition [bulk RNA-seq]

神经退行性机制

胶质细胞转录组学

The Christchurch mutation (R136S) on the APOE3 (E3S/S) gene is associated with attenuation of tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high levels of amyloid

NIAID Data Ecosystem00

IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy

资源简介：

相关数据集