Supplementary Material for: Renal-type clear cell carcinoma of the prostate: a rare case report

Occurrence of clear cell carcinoma of the prostate is exceedingly rare and presents a diagnostic dilemma. We describe a case of a 47-year- old male nonsmoker, who presented with a history of frequency dribbling urination and dysuria for six-months. In a digital rectal exam, enlarge prostate with a hard consistency was identified. All results for hematological and biochemical tests were normal. Also serum prostate-specific-antigen (PSA) level was 2.7 ng/ml (within normal range). Open prostatectomy was done and the result showed a 300 gr specimen and histopathology examination revealed clear cell carcinoma. Computerized tomography (CT) scan and ultrasound did not show any mass in kidneys but three nodules in both lungs in favor of metastasis were identified. Three months after surgery PET scan revealed hyperactivity in the abdominal wall, pelvic lymph nodes and lung fields in favor of metastasis thereafter systemic therapy with tyrosine kinase inhibitor was prescribed. To the best of our knowledge, clear cell carcinoma of the prostate has been reported very rarely.

前列腺透明细胞癌的发病率极低，且临床诊断颇具困境。本文报告1例47岁男性非吸烟者，该患者因尿频、尿滴沥及排尿困难症状持续6个月就诊。直肠指检（digital rectal exam）提示前列腺体积增大且质地坚硬。血液学及生化检查结果均正常，血清前列腺特异性抗原（prostate-specific-antigen, PSA）水平为2.7 ng/ml，处于正常参考范围内。行开放性前列腺切除术，术后标本重量为300克，组织病理学检查结果证实为透明细胞癌。计算机断层扫描（computed tomography, CT）及超声检查未发现肾脏占位，但双肺可见3枚结节，倾向于转移灶。术后3个月的正电子发射断层扫描（PET scan）显示腹壁、盆腔淋巴结及肺野存在代谢活跃灶，提示转移，随后予酪氨酸激酶抑制剂（tyrosine kinase inhibitor）行全身系统治疗。据我们所知，目前前列腺透明细胞癌的相关报道极为罕见。