Multivariate Cox proportional hazards analysis of genetic polymorphisms in relation to overall survival following breast cancer diagnosis, by ER status*.

*Analyses by ER status included data from 12 studies with information on vital status and ER status (CGPS, CNIO-BCS, HABCS, HEBCS, KBCP, kConFab, LUMCBCS, MCCS, PBCS, SASBCS, SBCS, SEARCH).**Per-allele hazard ratios (HR) and observed P values are adjusted for study. Allele changes are (common>rare based on frequencies in European populations): G>A for rs2981582; G>A for rs3803662; T>G for rs889312; A>G for rs13281615 and A>G for rs381798.***Permutation adjusted P values.****Per-allele hazard ratios (HR) and observed P values are adjusted for study, age at diagnosis (continuous), ER status and grade (continuous). Analyses limited to 11 studies with ER and grade information (CGPS, CNIO-BCS, HABCS, HEBCS, KBCP, LUMCBCS, MCCS, PBCS, SASBCS, SBCS, SEARCH).The P values for the interaction between ER status and genotype adjusted for study, grade and age at diagnosis are: 0.60, 0.15, 0.29, 0.45, 0.38 for rs2981582, rs3803662, rs889312, rs13281615, rs381798, respectively.

按雌激素受体（estrogen receptor，ER）状态开展的分析纳入了12项提供了生存状态与ER状态数据的研究，分别为CGPS、CNIO-BCS、HABCS、HEBCS、KBCP、kConFab、LUMCBCS、MCCS、PBCS、SASBCS、SBCS、SEARCH。
每条等位基因对应的风险比（hazard ratio，HR）及观测P值均经研究校正。等位基因的碱基替换方向（基于欧洲人群的等位基因频率，按常见至稀有排序）为：rs2981582为G>A；rs3803662为G>A；rs889312为T>G；rs13281615为A>G；rs381798为A>G。
P值经置换检验校正。
每条等位基因对应的风险比及观测P值均经研究、诊断年龄（连续变量）、ER状态及肿瘤分级（连续变量）校正。本次分析仅纳入11项同时提供ER状态与肿瘤分级数据的研究，即CGPS、CNIO-BCS、HABCS、HEBCS、KBCP、LUMCBCS、MCCS、PBCS、SASBCS、SBCS、SEARCH。
经研究、肿瘤分级及诊断年龄校正的ER状态与基因型交互作用的P值分别为：rs2981582对应0.60、rs3803662对应0.15、rs889312对应0.29、rs13281615对应0.45、rs381798对应0.38。