Expected GxE mechanisms.

Both genetic influences and neighborhood environments play a role in shaping life satisfaction. However, research examining gene-environment interactions (GxE) in this context remains limited. This study investigates how neighborhood deprivation moderates the effects of genetic influences on life satisfaction. Using data from 760 dizygotic (DZ) twin pairs in the German Twin Family Panel (TwinLife), we apply twin fixed-effect models to estimate GxE effects. Results indicate that a Polygenic index (PGI) for subjective well-being is positively associated with life satisfaction. Notably, this association is strongest among individuals living in moderately deprived neighborhoods, and weaker in both highly deprived and less deprived areas. Thus, there are signs of compensation in less deprived areas and, particularly, diathesis-stress/triggering in highly deprived areas.

遗传因素与邻里环境均对个体生活满意度的塑造发挥作用。然而，当前针对该领域内基因-环境交互作用（GxE）的相关研究仍较为有限。本研究旨在探讨邻里剥夺对遗传因素影响生活满意度的调节效应。本研究依托德国双生子家庭追踪调查（TwinLife）中760对异卵双生子（DZ）的样本数据，采用双生子固定效应模型对基因-环境交互效应进行估计。结果显示，主观幸福感多基因指数（PGI）与生活满意度呈显著正相关。值得注意的是，该相关性在居住于中等程度邻里剥夺环境的个体中最为显著，而在高度剥夺与低剥夺社区中均有所减弱。据此可见，低剥夺社区中存在补偿效应，而高度剥夺社区中则尤其表现出素质-应激/触发效应。