Sequential enhancer sequestration dysregulates recombination center formation at the IgH locus. Sequential enhancer sequestration dysregulates recombination center formation at the IgH locus

We reoprt that transcriptional level of distal VH is dependent of both intronic enhancer (Eµ) and intergenic control region 1 (IGCR1). Overall design: Examination of total RNA from different Pro-B cell lines.

我们在此报道，远端可变重链（distal VH）的转录水平同时依赖于内含子增强子（intronic enhancer, Eµ）与基因间调控区1（intergenic control region 1, IGCR1）。实验整体设计：对不同前B细胞系（Pro-B cell lines）的总RNA（total RNA）进行检测。