Intra-class correlation coefficient (ICC) is highest amongst the CANARY classes representing most invasive ADC features.

Intra-class correlation coefficient (ICC), a measure of agreement of quantitative assessments made by different observers evaluating the same quantity, was calculated for each CANARY class, the VIRO group, and the average (Avg.) of all classes. An ICC of 0.8–1 reflects high agreement between users. These calculations were performed for the VUMC/TVHS and the Mayo cohorts, as well as for each subgroup of patients scanned by a particular CT scanner (GE Medical Systems, Philips, and Siemens). ICCs and 95% CI for each voxel class are shown below. The number of patients within each cohort is listed in parentheses.组内相关系数（Intra-class correlation coefficient, ICC）是衡量不同评估者对同一量化指标评估结果一致性的指标。本研究针对各CANARY类、VIRO组以及所有类别的平均值（Avg.）分别计算了ICC。当ICC取值介于0.8~1之间时，代表评估者间具有高度一致性。上述计算分别针对VUMC/TVHS队列、梅奥（Mayo）队列，以及由特定CT扫描仪（通用电气医疗系统GE Medical Systems、飞利浦Philips、西门子Siemens）扫描的各患者亚组开展。各体素类别的ICC值及95%置信区间（95% CI）详见下文，各队列的入组患者数量标注于括号内。