Selection of LM695 to faster growth and increased MIC.

aDt; doubling time in min in LB medium at 37°C. bP-value; Significance of the difference in generation time relative to LM695, the parental strain, Students t-test for independent samples, n = 10 for each strain. cMutation; Identity of the new mutation identified in each evolved strain. dMIC; for ciprofloxacin (µg/ml) of LM695 and each of the evolved strains.aDt：37℃条件下LB培养基（LB medium）中的倍增时间，单位为分钟。 bP值（P-value）：相对于亲本菌株LM695的代时差异显著性，采用独立样本Student t检验，每个菌株的样本量n=10。 c突变（Mutation）：各进化菌株中鉴定到的新突变的具体信息。 d最低抑菌浓度（Minimum Inhibitory Concentration, MIC）：环丙沙星（ciprofloxacin）对LM695及各进化菌株的MIC值，单位为μg/ml。