Longitudinal_rsfMRI_TgF344-ADrats_4M_6M

In this project, longitudinal resting-state functional MRI was performed in the TgF344-AD rat model for Alzheimer's Disease. Male rats were scanned at 4-monhts of age and 6-months of age, respectively prior to the onset of amyloid-B plaques and at the early stage of amyloid-B plaque accumulation.

This data set has been used in the following publications:
1. van den Berg M, Adhikari MH, Verschuuren M, Pintelon I, Vasilkovska T, Van Audekerke J, Missault S, Heymans L, Ponsaerts P, De Vos WHet al (2022) Altered basal forebrain function during whole-brain network activity at pre- and early-plaque stages of Alzheimer's disease in TgF344-AD rats. Alzheimers Res Ther 14: 148 Doi 10.1186/s13195-022-01089-2
2. De Waegenaere S, van den Berg M, Keliris GA, Adhikari MH, Verhoye M (2024) Early altered directionality of resting brain network state transitions in the TgF344-AD rat model of Alzheimer's disease. Front Hum Neurosci 18: 1379923 Doi 10.3389/fnhum.2024.1379923

本研究针对阿尔茨海默病（Alzheimer's Disease）的TgF344-AD大鼠模型，开展了纵向静息态功能磁共振成像（resting-state functional MRI）扫描。实验选取雄性大鼠分别于4月龄与6月龄时进行成像：前者处于β淀粉样蛋白斑块（amyloid-B plaques）形成前期，后者处于β淀粉样蛋白斑块沉积的早期阶段。

本数据集已被应用于以下学术出版物：
1. van den Berg M、Adhikari MH、Verschuuren M、Pintelon I、Vasilkovska T、Van Audekerke J、Missault S、Heymans L、Ponsaerts P、De Vos WH等（2022）《TgF344-AD大鼠阿尔茨海默病预斑块与早期斑块阶段全脑网络活动中基底前脑功能异常》，Alzheimers Res Ther，14: 148，DOI: 10.1186/s13195-022-01089-2
2. De Waegenaere S、van den Berg M、Keliris GA、Adhikari MH、Verhoye M等（2024）《阿尔茨海默病TgF344-AD大鼠模型静息脑网络状态转换的早期方向性异常》，Front Hum Neurosci，18: 1379923，DOI: 10.3389/fnhum.2024.1379923