Data_Sheet_1_How to report and make sense of a new HIV-1 circulating recombinant form?.pdf

Co-circulation of multiple HIV-1 subtypes in the same high-risk groups leads to the on-going generation of various inter-subtype recombinants, including unique (URFs) and circulating (CRFs) recombinant forms, which brings a new challenge for the prevention and eradication of HIV/AIDS. Identification and prompt reporting of new CRFs will provide not only new insights into the understanding of genetic diversity and evolution of HIV-1, but also an early warning of potential prevalence of these variants. Currently, 140 HIV-1 CRFs have been described; however, their prevalence and clinical importance are less concerned. Apart from the mosaic genomic maps, less other valuable information, including the clinical and demographic data, genomic sequence characteristics, origin and evolutionary dynamics, as well as representative genomic fragments for determining the variants, are available for most of these CRFs. Accompanied with the growing increase of HIV-1 full-length genomic sequences, more and more CRFs will be identified in the near future due to the high recombination potential of HIV-1. Here, we discuss the prevalence and clinical importance of various HIV-1 CRFs and propose how to report and make sense of a new HIV-1 CRF.

同一高危人群中多种人类免疫缺陷病毒1型（HIV-1）亚型的共循环传播，持续产生各类亚型间重组体，包括独特重组型（URFs）与流行重组型（CRFs），这为艾滋病（HIV/AIDS）的预防与根除工作带来了全新挑战。对新型流行重组型（CRFs）的鉴定与及时上报，不仅能够深化我们对HIV-1遗传多样性与进化规律的认知，还可为这些变异株的潜在流行态势提供早期预警。目前已报道140种HIV-1流行重组型，但针对其流行率与临床重要性的研究与关注仍相对匮乏。除镶嵌式基因组图谱外，多数此类流行重组型仍缺乏其他有价值的研究数据，涵盖临床与人口统计学资料、基因组序列特征、起源与进化动态，以及用于鉴定该类变异株的代表性基因组片段。随着HIV-1全长基因组序列数据的持续积累，结合HIV-1极高的重组潜能，未来将有越来越多的流行重组型被鉴定出来。本文综述了各类HIV-1流行重组型的流行率与临床重要性，并就新型HIV-1流行重组型的报告与解析思路提出了建议。