pone.0330290.t006 -

Medical scientists have dual commitments to clinical care and research efforts. Such commitments can create hectic and stressful work schedules, which may impact on well-being and cognition. In this study, we tested the hypothesis that brief mindfulness coaching (three 1.5 hour online group sessions over 12 weeks) can benefit medical scientists. We conducted a waitlist-controlled intervention study (n = 43) with M.D./Ph.D. preclinical or graduate students and post M.D./Ph.D. trainees/faculty. Assessments of quantitative outcomes included self-reports of burnout, mindfulness, self-compassion, and well-being, as well as objective neuro-cognitive assessments. The results showed no effect of intervention on self-report measures. However, amongst cognitive measures, selective attention performance was significantly improved following the intervention (bias corrected effect size, Hedges’ g = 1.13, p = 0.005). Extent of improvement in selective attention correlated with suppression of visual alpha oscillations – a neural marker for distractibility – measured using electroencephalography (EEG) (r = −0.32, p Trial registration: The study was registered in the International Standard Randomized Controlled Trial Number Registry (ISRCTN16736293) at https://www.isrctn.com/.医学科研人员肩负临床诊疗与科研探索的双重职责。此类职责往往会催生繁忙高压的工作节律，进而对其身心健康与认知功能造成负面影响。本研究旨在验证一项假设：为期12周、包含3次1.5小时线上团体课程的简易正念辅导，可对医学科研人员产生积极效益。本研究开展了一项等待名单对照干预试验（n=43），受试者为医学博士/哲学博士（M.D./Ph.D.）临床前阶段学生、研究生，以及已获得M.D./Ph.D.学位的受训人员与教职人员。本研究的量化结局评估涵盖职业倦怠、正念水平、自我慈悲程度与身心健康状况的自评量表，以及客观神经认知评估。研究结果显示，干预措施对自评类测评结果无显著影响。但在认知测评指标中，干预后受试者的选择性注意表现得到了显著改善（偏差校正效应量赫奇斯g=1.13，p=0.005）。选择性注意的改善程度与视觉α节律——一种反映注意力分散性的神经标志物——的脑电（electroencephalography, EEG）抑制程度呈显著相关（r=-0.32，p<0.05）。试验注册：本研究已在国际标准随机对照试验注册号注册库（International Standard Randomized Controlled Trial Number Registry, ISRCTN16736293）完成注册，注册网址为https://www.isrctn.com/