Predictive effects of factors after cART initiation on progression to death and to new ADE.

cART, combination antiretroviral therapy; ADE, AIDS-defining event; py, person-years; CI, confidence interval.aEffects were estimated adjusted for a priori confounders, time since cART initiation, and current CD4 count, viral load and haemoglobin. Current CD4 count and haemoglobin, and CD4 count, viral load and haemoglobin at cART initiation were analysed as continuous variables.bTo present the estimated effect of CD4 count (fitted square root transformed) and current haemoglobin (fitted with additional cubic spline term), we derived from the fitted model the rate at the marker value at which 50% of person-years of follow-up falls above and below within each strata, and then calculated the corresponding rate ratios.cBased on patients without prior AIDS diagnosis before cART initiation. Only 1 patient was diagnosed with a severe ADE after starting cART, who had progressive multifocal leukoencephalopathy.