Predictive effects of factors after cART initiation on progression to death and to new ADE.

cART, combination antiretroviral therapy; ADE, AIDS-defining event; py, person-years; CI, confidence interval.aEffects were estimated adjusted for a priori confounders, time since cART initiation, and current CD4 count, viral load and haemoglobin. Current CD4 count and haemoglobin, and CD4 count, viral load and haemoglobin at cART initiation were analysed as continuous variables.bTo present the estimated effect of CD4 count (fitted square root transformed) and current haemoglobin (fitted with additional cubic spline term), we derived from the fitted model the rate at the marker value at which 50% of person-years of follow-up falls above and below within each strata, and then calculated the corresponding rate ratios.cBased on patients without prior AIDS diagnosis before cART initiation. Only 1 patient was diagnosed with a severe ADE after starting cART, who had progressive multifocal leukoencephalopathy.cART，即联合抗逆转录病毒疗法（combination antiretroviral therapy）；ADE，即艾滋病定义性事件（AIDS-defining event）；py，即人年（person-years）；CI，即置信区间（confidence interval）。a. 本研究估计的效应值已针对先验混杂因素、自cART启动后的时长，以及当前CD4计数、病毒载量与血红蛋白水平进行校正调整。当前CD4计数、血红蛋白水平，以及初始cART启动时的CD4计数、病毒载量和血红蛋白均作为连续变量开展分析。b. 为呈现CD4计数（经平方根拟合转换）与当前血红蛋白水平（附加三次样条项拟合）的估计效应，我们从拟合模型中提取各分层内随访人年50%分布于其两侧的标志物值对应的发生率，进而计算相应的发生率比。c. 本分析基于启动cART前未被诊断过艾滋病的患者。仅1例患者在启动cART后被诊断为严重ADE，其病症为进行性多灶性白质脑病。