Averaged total solvent accessible areas (SAAs) of WT and p.E27K SSBP1 were calculated from the last 100 ns of the molecular dynamics trajectory.

The SAAs of positively-charged residues (R and K) and negatively-charged residues (E and D) are also shown, along with the net positively-charged SAA calculated from the difference between positive and negative SAA. Monomers underlined are E27K. Highlight colors reflect differences from the WT tetramer in each category: yellow indicates reduction; blue indicates increase. ± reflects standard deviations.

本内容同时展示了带正电荷残基（精氨酸R与赖氨酸K）以及带负电荷残基（谷氨酸E与天冬氨酸D）的溶剂可及表面积（Solvent-Accessible Surface Area, SAA），还一并给出了通过正负SAA差值计算得到的净正电荷SAA。带有下划线的单体为E27K突变体。高亮颜色用于反映各分类中与野生型（Wild Type, WT）四聚体的差异：黄色代表该类指标相较于野生型降低，蓝色代表该类指标升高。±符号代表标准差。