Effect of obesity on aspirin action and its efficacy in colon cancer therapy

Primary objectives: To evaluate the effect of a short course (one week) of acetylsalicylic acid at different doses on platelet activation and platelet COX-1 activity in patients diagnosed with colorectal cancer, comparing these effects in obese and non-obese patients.
Primary endpoints: -Assessment of the level of COX enzyme acetylation in platelets and healthy and tumour colonic tissue as biomarkers of clinical efficacy.-Safety variables include analytical determinations with haemogram, biochemistry (blood and urine), microbiology and pregnancy test prior to inclusion in the trial, in order to detect abnormalities that imply exclusion criteria for the individual.

主要研究目标：评估为期1周的短疗程、不同剂量的乙酰水杨酸对结直肠癌确诊患者的血小板活化及血小板环氧合酶1（COX-1）活性的影响，并对比肥胖与非肥胖患者之间的此类效应差异。
主要研究终点：
- 检测血小板、健康结肠组织与肿瘤结肠组织中的环氧合酶（COX）乙酰化水平，将其作为临床疗效的生物标志物；
- 安全性变量包括受试者入组试验前的血常规、血液与尿液生化检测、微生物学检测及妊娠试验，用于排查符合个体排除标准的异常指标。