UPLC-HRMS-Based Untargeted Dynamic Metabolomics of Temporal Evolution in Glucose Metabolic States under Insulin Resistance

This study analyzed human serum samples from individuals across different stages of glycemic control, including normal glucose tolerance (NGT, n=25), isolated insulin resistance (IR, n=19), IR with impaired glucose regulation (IGR, n=32), and IR with type 2 diabetes mellitus (T2DM, n=33). Untargeted metabolomics was performed using UPLC-HRMS. The data are intended for the characterization of metabolic changes along this disease spectrum. Detailed results will be reported in a future publication.