Expression data from abdominal aorta of cutaneous inflammation mice. Expression data from abdominal aorta of cutaneous inflammation mice

Vascular disorder such as arteriosclerosis is one of the serious complications of chronic inflammatory skin diseases. We employed spontaneous dermatitis model mice overexpressing human caspase-1 in the epidermal keratinocyte (KCASP1Tg). GeneChip were performed to measure the changes in mRNA levels in the abdominal aorta. Overall design: The mRNA was extracted from the abdominal aorta of 4-month-old KCASP1Tg and WT mice, and GeneChip analysis was performed. There were several upregulated genes in KCASP1Tg mice.

动脉粥样硬化等血管疾病是慢性炎症性皮肤病的严重并发症之一。我们采用了在表皮角质形成细胞（epidermal keratinocyte）中过表达人半胱天冬酶-1（caspase-1）的自发性皮炎模型小鼠（KCASP1Tg）。通过基因芯片（GeneChip）检测腹主动脉中的mRNA水平变化。实验设计概述：从4月龄KCASP1Tg小鼠与野生型（WT）小鼠的腹主动脉中提取mRNA，进行基因芯片分析。结果显示，KCASP1Tg小鼠体内存在多个上调基因。