Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600), a non-nucleoside inhibitor
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Crystal Structure of HIV-1 Reverse Transcriptase (Y181C, V106A) variant in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-2-naphthonitrile (JLJ600), a non-nucleoside inhibitor Descriptor: 1,2-ETHANEDIOL, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}naphthalene-2-carbonitrile, MAGNESIUM ION, ... Authors: Hollander, K, Jorgensen, W.L, Anderson, K.S. Deposit date: 2023-05-11 Release date: 2023-11-29 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.78 Å) Cite: Exploring novel HIV-1 reverse transcriptase inhibitors with drug-resistant mutants: A double mutant surprise. Protein Sci., 32, 2023
HIV-1逆转录酶（HIV-1 Reverse Transcriptase）Y181C、V106A突变体与非核苷类抑制剂（non-nucleoside inhibitor）5-(2-(2-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)乙氧基)苯氧基)-2-萘甲腈（JLJ600）的复合物晶体结构。组分信息包括1,2-乙二醇、5-{2-[2-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)乙氧基]苯氧基}萘-2-甲腈、镁离子等。作者：Hollander K、Jorgensen W.L.、Anderson K.S.。提交日期：2023-05-11，发布日期：2023-11-29，最后修改日期：2023-12-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.78埃（Å）。引用文献：《探索针对耐药突变株的新型HIV-1逆转录酶抑制剂：一次双突变体的意外发现》，《Protein Sci.》，第32卷，2023年
