WP400 - p38 MAPK signaling - Homo sapiens

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP400).

p38丝裂原活化蛋白激酶（p38 MAPKs）是丝裂原活化蛋白激酶（MAPK）家族的成员，可被多种环境应激及炎症细胞因子激活。应激信号通过Rho家族小GTP酶（Rac、Rho、Cdc42）的成员传递至该信号级联反应。与其他MAPK级联反应类似，该通路的膜近端组分为MAPKKK，通常为MEKK或混合谱系激酶（MLK）。MAPKKK可磷酸化并激活p38 MAPK的激酶MKK3/5。MKK3/6亦可直接被凋亡刺激激活的ASK1所激活。p38 MAPK参与调控热休克蛋白27（Hsp27）、丝裂原活化蛋白激酶激活的蛋白激酶2（MAPKAP-2）以及包括激活转录因子2（ATF2）、信号转导与转录激活因子1（STAT1）、Max/Myc复合物、肌细胞增强因子2（MEF-2）、ELK-1在内的多种转录因子，还可通过激活丝裂原与应激激活蛋白激酶1（MSK1）间接调控环腺苷酸应答元件结合蛋白（CREB）。

该通路相关蛋白可通过[CPTAC检测门户（CPTAC Assay Portal）](https://assays.cancer.gov/available_assays?wp_id=WP400)获取靶向检测服务。