The COLCATS study: Identification of an anti-apoptotic druggable target signature for the treatment of colorectal cancer. Homo sapiens

This study investigates the correlation between gene overexpression and resistance to apoptosis and hyper-proliferative phenotype in colorectal cancer. We analyzed the transcriptome of a cohort of xenografted colorectal tumors and primary resected biopsies together with normal tissue datasets and identified a set of genes overexpressed in colon cancer. KEYWORDS: transcription-profile, colon, colon-cancer, xenograft Overall design: In total 203 samples (101 new samlpes plus 102 samples already on GEO) were analyzed, they represent 4 different types : colon cancer, colon cancer mouse xenograft, colon cancer cell line, and normal colon.

本研究探讨了结直肠癌中基因过表达与细胞凋亡抵抗及过度增殖表型之间的关联。我们对一组异种移植结直肠肿瘤、原发性切除活检组织的转录组，以及正常组织数据集进行了分析，并鉴定出一组在结肠癌中过表达的基因。
关键词：转录谱（transcription-profile）、结肠、结肠癌
整体实验设计：本研究共分析203例样本（含101例新增样本与102例已收录于GEO的样本），涵盖4种类别：结肠癌、结肠癌小鼠异种移植瘤、结肠癌细胞系及正常结肠组织。