The top upstream regulators of WA target genes ranked according to the Activation Z-score (≥ ±2) and p-value.

TR- Transcription regulator; O- Other; K- Kinase; LDNR- Ligand dependent nuclear receptor. * TP53 and E2F1 transcription factors were selected for further analysis based on the lowest p-values in MDA-MB-231 despite lower than ±2 Activation Z-score.TR- 转录调控因子（Transcription regulator）；O- 其他；K- 激酶（Kinase）；LDNR- 配体依赖性核受体（Ligand dependent nuclear receptor）。* 尽管其激活Z评分低于±2，但基于MDA-MB-231细胞中的最低P值，选取TP53与E2F1转录因子进行后续分析。