Identification of Antigen B Gene Polymorphism of Echinococcus granulosus. Echinococcus granulosus

Cystic echinococcosis (CE) is a zoonotic infection caused by larval (metasestod) stages of sestodes belonging to the genus Echinococcus and the Taeniidae family. CE, Turkey, Mediterranean countries, Middle East, South America, New Zealand and South Africa are endemic. Molecular analysis has shown that E. granulosus can be divided into 10 genotypes, which correspond to the strain definition. E. granulosus produces a lipoprotein known as Echinococcus granulosus Antigen B (EgAgB). EgAgB has been reported as an immunoregulatory molecule that elicits both cellular and humoral immune responses in intermediate hosts and takes part in some of the host-parasite interactions responsible for parasite survival in hydatid cyst. In this study; The EgAgB polymorphism study is aimed to be performed in KE materials to be obtained from intermediate hosts using molecular techniques. In this way, it is aimed to contribute to the implementation of effective control programs against CE disease by regional and country basis by revealing the genotype-antigenic polymorphism relationship in our region.

囊型棘球蚴病（Cystic echinococcosis, CE）是一种由棘球绦虫属（Echinococcus）、带科（Taeniidae）绦虫的幼虫（囊尾蚴）阶段引发的人畜共患传染病。CE在土耳其、地中海国家、中东、南美、新西兰及南非均呈地方性流行。分子生物学分析显示，细粒棘球绦虫（E. granulosus）可划分为10个基因型，对应现行的虫株定义。细粒棘球绦虫可分泌一种脂蛋白，即细粒棘球绦虫抗原B（Echinococcus granulosus Antigen B, EgAgB）。已有研究表明，EgAgB是一种免疫调节分子，可在中间宿主体内诱发细胞免疫与体液免疫应答，并参与保障寄生虫在棘球蚴囊内存活的部分宿主-寄生虫互作过程。本研究拟采用分子技术，对从中间宿主体内获取的KE材料开展EgAgB多态性研究。本研究旨在明确本地区的基因型-抗原多态性关系，进而为基于区域及国家层面的CE有效防控方案的落地实施提供科学参考。