Touch receptor end-organ innervation and function requires sensory expression of the transcription factor Meis2

To better understand the molecular changes underlying tactile defects in Meis2 mutant mice, we performed bulk RNAseq analysis on Dorsal Root Ganglia (DRG) dissected form WT, Isl1Cre/+ and Isl1Cre/+::Meis2LoxP/LoxP E18.5 embryos Comparative gene expression profiling analysis of RNA-seq data for DRG WT, Isl1Cre/+ and Isl1Cre/+::Meis2LoxP/LoxP E18.5 embryos

为深入解析Meis2突变小鼠触觉缺陷背后的分子变化机制，我们对野生型（WT）、Isl1Cre/+及Isl1Cre/+::Meis2LoxP/LoxP品系胚胎发育第18.5天（E18.5）的小鼠胚胎背根神经节（Dorsal Root Ganglia, DRG）开展了批量RNA测序（bulk RNAseq）分析，并针对上述三类样本的RNA测序数据完成了比较基因表达谱分析。