Protein prenylation drives discrete signaling programs for the differentiation and maintenance of effector Treg cells [Pggt1b_ATACseq]

An interplay between immune signals, isoprenoids-mediated protein prenylation, and intracellular signaling for the differentiation and maintenance of eTreg cells. Overall design: ATAC-seq was performed to compare chromatin accessibility of WT, Pggt1b-deficient cTreg and eTreg cells from mixed bone marrow chimera

本数据集聚焦免疫信号、类异戊二烯（isoprenoids）介导的蛋白质异戊二烯化（protein prenylation），与调控效应性调节性T细胞（eTreg cells）分化及维持的细胞内信号通路之间的相互作用。实验整体设计：采用ATAC-seq技术，对比混合骨髓嵌合体（mixed bone marrow chimera）来源的野生型（WT）、Pggt1b基因缺陷型经典调节性T细胞（cTreg cells）与效应性调节性T细胞（eTreg cells）的染色质可及性差异。