scRNASeq data of CD45+CD3-CD19- and keratinocytes in normal and HS skin. scRNASeq data of CD45+CD3-CD19- and keratinocytes in normal and HS skin

Hidradenitis suppurativa (HS) is a highly prevalent, morbid inflammatory skin disease with limited treatment options. The major cell types and inflammatory pathways in skin of HS patients are poorly understood. We profiled via scRNASeq myeloid cells and keratinocytes sort-purified from two healthy skin samples and two samples with HS pathology to determine major cell types and transcriptional pathways altered in HS. Overall design: scRNASeq of myeloid immune cells and keratinocytes profiled in healthy appearing skin versus skin with hidradenitis suppurativa pathology

化脓性汗腺炎（Hidradenitis suppurativa, HS）是一种患病率高、病情严重且治疗选择有限的炎症性皮肤病。目前学界对HS患者皮肤内的主要细胞类型与炎症通路仍不甚明晰。为明确HS中发生异常改变的主要细胞类型与转录通路，本研究通过单细胞RNA测序（scRNASeq）技术，对2份健康皮肤样本与2份HS病变皮肤样本中分选纯化得到的髓系细胞与角质形成细胞开展转录组图谱分析。实验设计：对外观健康的皮肤与化脓性汗腺炎病变皮肤中的髓系免疫细胞与角质形成细胞进行scRNASeq分析。