The Binding Prediction Model of The Iron-responsive Element Binding Protein and Iron-responsive Elements

Iron is essential to fulfilling an indispensable role in the biological process in human physiology. Various proteins were known involved in iron metabolism. One of the proteins called iron-responsive element binding protein (IRP) which acts as master iron of cellular iron homeostasis. There are two IRP known to date, which is: IRP1 and IRP2. Previous studies showed IRP bind to iron-responsive elements (IRE) located in 5’-UTR of the transferrin receptor 1. The interaction of IRP/IRE is well studied through many years to find a better treatment for the cellular disorder in iron metabolism. However, the structural differences of both IRP and the binding prediction model of IRP/IRE remain unclear. This dataset provides structure predictions of IRP/IRE by using reliable bioinformatics tools .

铁在人体生理学的生物学过程中发挥着不可或缺的关键作用。目前已知多种蛋白质参与铁代谢过程。其中一类名为铁应答元件结合蛋白（iron-responsive element binding protein, IRP）的蛋白质，是细胞铁稳态的核心调控因子。截至目前，已发现两种IRP，分别为IRP1与IRP2。既往研究表明，IRP可结合于转铁蛋白受体1（transferrin receptor 1）5'非翻译区（5'-Untranslated Region, 5'-UTR）内的铁应答元件（iron-responsive element, IRE）。多年来，科研人员对IRP/IRE的相互作用开展了大量研究，旨在为铁代谢相关细胞紊乱开发更优的治疗手段。然而，两种IRP之间的结构差异，以及IRP/IRE的结合预测模型，目前仍未明确。本数据集通过可靠的生物信息学工具，提供了IRP/IRE的结构预测结果。