Synthesis of Functionalized-Magnetic Nanoparticles and Application as a Retrievable and Efficient Catalyst for the Green Synthesis of Pyrano[2,3-c]Phenazine-15-yl)Methanone Derivatives Under Solvent-Free Conditions

A novel method for the synthesis of four-component pyrano[2,3-c]phenazin-15-yl) methanone derivatives has been developed via condensation/Knoevenagel/Michael in the presence of Fe3O4@ZnO-SO3H as a recyclable heterogeneous catalyst under Solvent-Free Conditions, using microwave irradiation. This green process has many advantages such as high productivity, shorter reaction times, environmentally friendly, quick isolation, and prevention of hazardous solvents in the laboratory for the synthesis of pyrano[2,3-c]phenazin-15-yl)methanone derivatives, which are promising compounds in various aspects of medical sciences (pharmacy).本研究开发了一种合成四组分吡喃并[2,3-c]吩嗪-15-基甲酮衍生物的新颖方法：以Fe3O4@ZnO-SO3H作为可回收多相催化剂，在无溶剂条件下结合微波辐照，通过缩合/克脑文盖尔（Knoevenagel）/迈克尔（Michael）串联反应完成合成。该绿色合成工艺具备多项优势，包括产率优异、反应时长更短、环境友好、分离便捷，且可避免实验室在合成该类衍生物时使用有害溶剂。而吡喃并[2,3-c]吩嗪-15-基甲酮衍生物在医学科学（药学）的诸多领域均为极具应用前景的化合物。