Comparison of Previously Reported Associations to AIS with Results from the Present Study.

The marker rs11190870 at LBX1 is significantly associated in our European population while rs6570507 at GPR126 is nominally associated in the present study. Our study does not show evidence of association to AIS in CHL1 and SOX9. The marker rs10510181 at CHL1 was originally identified in a European population while markers at GPR126, LBX1 and SOX9 were discovered in Asian populations. rs10510181 and rs11190870 were imputed in this study. Previously Published Data reported from [14, 19, 30].Comparison of Previously Reported Associations to AIS with Results from the Present Study.本研究针对欧洲人群开展分析，结果显示位于LBX1基因的遗传标记rs11190870与目标表型存在显著关联；而位于GPR126基因的rs6570507仅呈现统计学名义关联。本研究未发现CHL1与SOX9基因位点与青少年特发性脊柱侧凸（Adolescent Idiopathic Scoliosis, AIS）存在关联的证据。位于CHL1基因的rs10510181遗传标记最初是在欧洲人群中被鉴定得到的，而GPR126、LBX1及SOX9基因的相关遗传标记则是在亚洲人群中发现的。本研究对rs10510181与rs11190870进行了基因型填充（genotype imputation）。本研究所引用的既往已发表数据来自文献[14, 19, 30]。现将既往报道的青少年特发性脊柱侧凸关联研究结果与本研究结果进行对比。