Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment [RNA-Seq]

This study demonstrates the relationship between replication timing, transcription and chromatin compartments in human stem cell differenatiation to endoderm lineage. Measuring replication timing, transcription and chromatin organization using Hi-C at different time points during human stem cell differentiation to endoderm lineage.

本研究揭示了人类干细胞向内胚层谱系分化过程中，复制时序、转录与染色质区室三者之间的关联。本研究在人类干细胞向内胚层谱系分化的不同时间节点，采用Hi-C技术对复制时序、转录水平及染色质组织状态进行检测。