p21 peptide simulation data. Dataset includes imaged trajectory files for the five Pep-GaMD simulations runs. We have also provided the topology and the pdb file.

Insights into the structural dynamic mechanism of PC1 activation by TA peptide agonists p9, p17 and p21 to provide an in-depth understanding that will facilitate development of therapeutics targeting PC1 for ADPKD by targeting PC1treatment.

本研究通过解析TA肽类激动剂p9、p17及p21激活多囊蛋白1（PC1）的结构动力学机制，以获取深入的理论认知，进而推动针对常染色体显性遗传性多囊肾病（Autosomal Dominant Polycystic Kidney Disease，ADPKD）的PC1靶向治疗药物的开发。