Regulation of fin regeneration by a voltage-gated sodium channel

We compare the brain and fin RNA-seq profiles of wild-type and scn8ab mutant zebrafish, which exhibit locomotion and fin regeneration defects. Biological duplicate brain and fin profiles of adult wild-type sibling and scn8ab(temca) mutant zebrafish. Corresponding sample pools include: whole brain of wild-type siblings and temca mutants and uninjured and 36 hpa fins of wild-type siblings and temca mutants at the restrictive temperature (33 degrees)

本研究对野生型与scn8ab突变型斑马鱼的脑及鳍的RNA测序（RNA-seq）转录组谱开展比较分析，该类突变体可表现出运动障碍与鳍再生缺陷。本研究包含成年野生型同窝对照与scn8ab(temca)突变型斑马鱼的脑和鳍的生物学重复样本。对应的样本池包括：在限制性温度（33摄氏度）下的野生型同窝对照及temca突变体的全脑组织，以及同一温度下二者的未损伤鳍与截肢后36小时（hpa）的鳍组织。