Neurotoxic and Behavioral Outcomes Data Following Polychlorinated Biphenyl (PCB) Exposure in Post-Weaned Rodents

This dataset accompanies a scoping review examining the neurotoxic outcomes of post-weaning exposure to polychlorinated biphenyls (PCBs) in rodent models. The dataset compiles results from a systematic literature search across PubMed, Embase, and Scopus, conducted according to PRISMA guidelines. Screening and data extraction were performed through a hybrid human–AI workflow that integrated manual review with automated screening via ChatGPT. The dataset includes ChatGPT’s classification outputs for title/abstract and methods screening, reviewer selections for calculating inter-rater reliability (Cohen’s and Fleiss’ kappa), and extracted data from full-text analyses of the included studies. Thirty-five studies met the inclusion criteria, representing diverse PCB congeners and mixtures administered to mice and rats during adolescence or adulthood. Extracted parameters include species, strain, sex, exposure window, dose, route of administration, and reported neurotoxic and behavioral outcomes. Neurotoxic endpoints encompassed oxidative stress, calcium signaling disruption, alterations in neurotransmitter levels, apoptosis, and changes in gene expression, while behavioral outcomes included effects on locomotion, anxiety, learning, memory, and cognitive flexibility. The dataset provides a record of screening decisions, methodological reproducibility, and synthesized study characteristics.

本数据集配套一项范围综述（scoping review），该综述旨在探究啮齿动物模型中断奶后暴露于多氯联苯（polychlorinated biphenyls，PCBs）所引发的神经毒性结局。本数据集整合了依据PRISMA指南开展的、针对PubMed、Embase及Scopus的系统文献检索结果。筛查与数据提取通过人机结合的工作流程完成，该流程将人工审阅与基于ChatGPT的自动化筛查相结合。数据集包含ChatGPT针对标题/摘要及方法学筛查的分类输出、用于计算评定者间信度（科恩kappa系数与弗莱希kappa系数）的审阅者遴选结果，以及纳入研究的全文分析提取数据。共有35项研究符合纳入标准，涵盖在青春期或成年期向小鼠和大鼠施加的多种多氯联苯同系物及混合物暴露方案。提取的参数包括物种、品系、性别、暴露窗口期、给药剂量、给药途径，以及所报告的神经毒性与行为学结局。神经毒性终点涵盖氧化应激、钙信号通路紊乱、神经递质水平改变、细胞凋亡及基因表达变化；行为学结局则涉及运动能力、焦虑样行为、学习、记忆与认知灵活性相关影响。本数据集完整记录了筛查决策、方法学可重复性及经整合的研究特征。