Table1_The inverse relationship between Life’s Essential 8 and risk of metabolic syndrome: evidence from NHANES 2005-2018.docx

BackgroundMetabolic syndrome (MetS) has a close association with cardiovascular diseases. Few studies have investigated the association of Life’s Essential 8 (LE8), the updated measurement of cardiovascular health (CVH), with MetS.
MethodsThe National Health and Nutrition Examination Survey (2005–2018) data was extracted. The LE8 comprised 4 health behaviors (diet, physical activity, nicotine exposure, and sleep health) and 4 health factors [body mass index (BMI), blood lipids, blood glucose, and blood pressure (BP)]. The total LE8 score is the average of 8 metric scores (0-100), categorized into low (0–49), moderate (50–79), and high CVH (80–100) levels. Multivariable logistic regression models, restricted cubic spline models and stratified analyses were performed to examine the relationship between LE8 and MetS.
ResultsIn this study, a total of 21,543 participants represented 146.6 million non-institutionalized U.S. adults. Following adjustment for various potential covariates, participants who attained a moderate [adjusted odds ratio (AOR) = 0.234, 95% CI: 0.209, 0.262] or a high CVH level (AOR = 0.026, 95% CI: 0.021, 0.032) exhibited an inverse correlation with MetS risks when comparing those with a low CVH level. An inverse linear dose-response relationship between LE8 scores and MetS risks was also identified (P for nonlinearity > 0.05).
ConclusionsLE8 was inversely associated with the risk of MetS. Adhering to LE8 guidelines to sustain a higher CVH level may be beneficial for preventing MetS.

研究背景：代谢综合征（Metabolic syndrome, MetS）与心血管疾病存在紧密关联。目前针对心血管健康新版评估体系——生命必需8项指标（Life’s Essential 8, LE8）与代谢综合征之间相关性的研究尚少。
研究方法：本研究提取了美国国家健康与营养检查调查（2005–2018年）的数据。LE8包含4项健康行为（饮食、身体活动、尼古丁暴露、睡眠健康）与4项健康因素[体质指数（body mass index, BMI）、血脂、血糖、血压（blood pressure, BP）]。LE8总评分为8项指标得分的平均值（0~100分），并被划分为低（0~49分）、中（50~79分）、高（80~100分）三级心血管健康水平。本研究采用多因素logistic回归模型、限制性立方样条模型及分层分析，以探究LE8与代谢综合征的关联。
研究结果：本研究共纳入21543名参与者，其对应的美国非机构化成年人群规模达1.466亿。在校正各类潜在混杂变量后，与低心血管健康水平者相比，心血管健康水平中等[校正后比值比（adjusted odds ratio, AOR）=0.234，95%置信区间（confidence interval, CI）：0.209, 0.262]或高水平者（AOR=0.026，95%CI：0.021, 0.032）的代谢综合征发病风险呈显著负相关。此外，本研究还发现LE8评分与代谢综合征风险间存在线性剂量反应关系（非线性检验P>0.05）。
研究结论：LE8与代谢综合征发病风险呈负相关。遵循LE8指南以维持较高的心血管健康水平，或可有效预防代谢综合征。