Effects of fenretinide treatment on gene expression in liver from high-fat diet fed male mice.

To investigate the effects of long-term high-fat diet (HFD)-feeding and short and long-term fenretinide treatment on mouse liver gene expression. Overall design: We performed gene expression analysis in liver tissue taken from four groups, mice fed HFD +/- 0.04% Fenretinide for 7 days or 20 weeks.

本研究旨在探究长期高脂饮食（high-fat diet, HFD）喂养以及短期、长期芬维A胺（fenretinide）处理对小鼠肝脏基因表达的影响。总体实验设计：我们对取自四组小鼠的肝脏组织进行基因表达分析，四组小鼠分别为：喂食高脂饮食7天、喂食高脂饮食并添加0.04%芬维A胺7天、喂食高脂饮食20周，以及喂食高脂饮食并添加0.04%芬维A胺20周。