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Mutations were made at various residues in two regions on interest (the Cap region and internal fusion loop region) of the MARV GP.

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https://figshare.com/articles/dataset/Mutations_were_made_at_various_residues_in_two_regions_on_interest_the_Cap_region_and_internal_fusion_loop_region_of_the_MARV_GP_/13717692
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Summary of the pseudotyped mutant virus infectivity and inhibition with Toremifene. The mutants in the cap region with % infectivity in brackets suggested there might be a shift in potency when tested with Toremifene at 10 uM. Full dose response curves were performed for these mutants and there was no change in potency. (XLSX)

托瑞米芬(Toremifene)处理下假型突变病毒感染性与抑制效果总结。 帽区(cap region)突变体的括号中标注了感染性百分比,提示在使用10 μM托瑞米芬进行测试时,其药效可能发生偏移。针对这些突变体开展了完整的剂量反应曲线实验,结果显示其药效并未发生改变。 (XLSX)
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2021-02-04
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