Raw Data for the article: Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart Human Model

In ascending thoracic aortic aneurysms (ATAAs), aneurysm kinematics are driven by ventricular traction occurring every heartbeat, increasing the stress level of dilated aortic wall. Aortic elongation due to heart motion and aortic length are emerging as potential indicators of adverse events in ATAAs; however, simulation of ATAA that takes into account the cardiac mechanics is technically challenging. The objective of this study was to adapt the realistic Living Heart Human Model (LHHM) to the anatomy and physiology of a patient with ATAA to assess the role of cardiac motion on aortic wall stress distribution. Patient-specific segmentation and material parameter estimation were done using preoperative computed tomography angiography (CTA) and ex vivo biaxial testing of the harvested tissue collected during surgery. The lumped-parameter model of systemic circulation implemented in the LHHM was refined using clinical and echocardiographic data. The results showed that the longitudinal stress was highest in the major curvature of the aneurysm, with specific aortic quadrants having stress levels change from tensile to compressive in a transmural direction. This study revealed the key role of heart motion that stretches the aortic root and increases ATAA wall tension. The ATAA LHHM is a realistic cardiovascular platform where patient-specific information can be easily integrated to assess the aneurysm biomechanics and potentially support the clinical management of patients with ATAAs.针对胸主动脉升部动脉瘤（ascending thoracic aortic aneurysms, ATAAs），其动脉瘤运动学由每一次心跳产生的心室牵拉所驱动，会升高扩张主动脉壁的应力水平。由心脏运动引发的主动脉伸长及主动脉长度，正逐渐成为ATAAs不良事件的潜在预测指标；然而，兼顾心脏力学的ATAAs模拟在技术层面仍颇具挑战。本研究旨在将逼真活体心脏人体模型（Living Heart Human Model, LHHM）适配至ATAAs患者的解剖与生理特征，以评估心脏运动对主动脉壁应力分布的影响。研究采用术前计算机断层血管造影（computed tomography angiography, CTA）及术中获取组织的离体双轴拉伸试验，完成了患者特异性影像分割与材料参数估算。依托LHHM构建的体循环集总参数模型，结合临床与超声心动图数据进行了优化。研究结果显示，动脉瘤主曲率处的纵向应力最高，特定主动脉象限的应力水平沿透壁方向由拉应力转变为压应力。本研究揭示了心脏运动的关键作用——其可牵拉主动脉根并升高ATAAs壁的张力。该ATAAs适配版LHHM是一套逼真的心血管研究平台，可便捷整合患者特异性信息以评估动脉瘤生物力学特征，进而有望为ATAAs患者的临床管理提供支持。