MI analysis in CA3-CA1 network in Con and Mel groups.

A & B. The modulation index as a function of analytic amplitude (30 to 70 Hz) and phase (1 to 20 Hz) in CA3, CA3-CA1 and CA1 in both Con and Mel groups. The higher MI value the stronger cross frequency coupling. C. Statistical MI data of phase-amplitude coupling between theta and gamma rhythms in hippocampal CA3-CA1 network. *P<0.05 for comparison between Con group and Mel group. D. Scatter plot of CA3 MI data vs. CA3-CA1 MI data for all normal and melamine-treated rats. E. Scatter plot of CA3-CA1 MI data vs. CA1 MI data for all normal and melamine-treated rats.

A、B板块：展示了对照组（Con）与三聚氰胺组（Mel）大鼠海马CA3区、CA3-CA1通路及CA1区中，调制指数（modulation index，MI）随解析振幅（30~70 Hz）与相位（1~20 Hz）的变化关系。调制指数数值越高，跨频率耦合越强。C板块：海马CA3-CA1网络内θ节律（theta rhythm）与γ节律（gamma rhythm）的相位-振幅耦合调制指数统计数据，对照组与Mel组间比较的显著性差异标准为*P<0.05。D板块：所有正常及三聚氰胺处理大鼠的海马CA3区调制指数与CA3-CA1通路调制指数的散点图。E板块：所有正常及三聚氰胺处理大鼠的海马CA3-CA1通路调制指数与海马CA1区调制指数的散点图。