Data from: Multicellular dynamics in HBV-associated FL

Evolutionary trajectories among malignant B cells illustrated disease progression of associated with HBV infection. The multicellular landscape of malignant cells and follicular dendritic cell (FDC) clusters was redefined through molecular stratification based on dynamic HBV-infected states. By integrating spatial and cellular profiles, a memory B cell-like cluster of malignant cells was identified, transitioning from atypical malignant cells. This transition provides a roadmap for developing targeted therapies aimed at modulating immunocyte interactions.恶性B细胞的进化轨迹阐明了与乙型肝炎病毒（HBV）感染相关的疾病进展过程。研究团队通过基于动态HBV感染状态的分子分层分析，重新界定了恶性细胞与滤泡树突状细胞（FDC）簇的多细胞图谱。通过整合空间与细胞表征数据，研究人员鉴定出一类由非典型恶性细胞转变而来的记忆B细胞样恶性细胞簇。该转变过程为开发调控免疫细胞相互作用的靶向治疗方案提供了指导路线图。