NHLBI TOPMed - NHGRI CCDG: Malmo Preventive Project (MPP)

The Malmö Preventive Project (MPP) was a community-based disease prevention program including 33,346 inhabitants from the city of Malmö in Southern Sweden. Complete birth cohorts between 1921-1949 were invited, and the participation rate was 71%. Participants underwent screening between 1974 to 1992 for cardiovascular risk factors, alcohol abuse, and breast cancer. Between 2002-2006, surviving participants were invited to a reexamination which included blood sampling from which DNA has been extracted. Subjects with prevalent or incident AF were identified from national registers as previously described, and cases with DNA were then matched in a 1:1 fashion to controls with DNA from the same cohort by sex, age (±1 year), and date of baseline exam (±1 year). Also, controls required a follow-up exceeding that of the corresponding AF case.

马尔默预防项目（Malmö Preventive Project, MPP）是一项基于社区的疾病预防项目，纳入瑞典南部马尔默市的33346名常住居民。该项目邀请了1921年至1949年出生的完整出生队列人群，整体参与率达71%。参与者于1974年至1992年间接受了心血管危险因素、酒精滥用及乳腺癌相关筛查。2002年至2006年，仍存活的参与者受邀接受复查，本次复查采集了血液样本并从中提取了DNA。研究人员通过国家登记册识别出既往存在或新发心房颤动（AF）的受试者，具体方法如既往所述；随后将携带DNA的心房颤动病例以1:1的比例，按照性别、年龄（±1岁）、基线检查日期（±1年），与同一队列中携带DNA的对照个体进行匹配。此外，对照个体的随访时长需长于对应的心房颤动病例。