Data Sheet 1_Preoperative diagnosis of primary ovarian lymphoma: a case report and a decade of insights.pdf

Through a comprehensive retrospective analysis of a 52-year-old woman with primary ovarian lymphoma (POL) and a review of similar cases over the past decade in the PubMed database, we gained several key insights into improving the understanding of POL among clinicians and radiologists for accurate diagnosis. POL is more prevalent among women in their 40s and usually presents with clinical manifestations of a solid mass (typically over 10 cm) and abdominal pain with B symptoms. Four imaging features show promise as indicators of potential diagnostic value in POL: the ovarian retention sign, touching ovaries, vascular floatation, and the sandwich sign. More than half of primary ovarian diffuse large B-cell lymphoma (DLBCL) cases have elevated lactate dehydrogenase (LDH) or carbohydrate antigen 125 (CA-125) levels. This comprehensive understanding of POL suggests that the combination of these four imaging features with elevated levels of CA-125 and LDH might help in the diagnosis of POL preoperatively, preventing unnecessary surgical interventions.

本研究通过对1例52岁原发性卵巢淋巴瘤（primary ovarian lymphoma, POL）女性患者开展全面回顾性分析，并结合PubMed数据库近10年的同类病例文献进行综述，以期加深临床医师与放射科医师对POL的认知，助力其实现精准诊断。原发性卵巢淋巴瘤多见于40~49岁女性，典型临床表现为实性肿块（通常直径＞10cm）、腹痛伴B症状。研究证实四项影像学特征对POL具有潜在诊断价值：卵巢潴留征、触诊卵巢征、血管漂浮征及夹心征。超过半数的原发性卵巢弥漫大B细胞淋巴瘤（diffuse large B-cell lymphoma, DLBCL）患者存在乳酸脱氢酶（lactate dehydrogenase, LDH）或糖类抗原125（carbohydrate antigen 125, CA-125）水平升高的情况。上述对POL的全面认知表明，将上述四项影像学特征与CA-125及LDH水平升高相结合，或可实现POL的术前诊断，从而避免不必要的外科干预。