Data Sheet 1_A review of Psoralea corylifolia L.: a valuable plant with profound biological significance.docx

Psoralea corylifolia L. (PCL) is an annual herb of the genus Psoralea in the family Fabaceae, and its mature fruit can be used medicinally as a precious medicinal herb to tonify muscles and bones. With the deepening of research, its applications to various industries, including food, agriculture, and cosmetics, with products being developed in countries such as Vietnam, India, and Japan. A total of 321 metabolites, including coumarins, flavonoids, meroterpenes, benzofurans, and dimers, were identified in PCL. PCL and related products have demonstrated therapeutic effects, such as antiosteoporosis effects, estrogen-like effects, anti-inflammatory properties, neuroprotection, antitumor activity, and vitiligo treatment. The expression mechanisms of these pharmacological effects are closely related to the regulation of the immune system, the inhibition of oxidative stress, and the induction of apoptosis. This paper summarizes the latest research on the ethnobotany, phytochemistry, processing technology, pharmacology, and hepatotoxicity of PCL. Furthermore, bibliometric analysis was used to systematically analyze the research hotspots and trends in PCL, which have never been addressed in previous reviews of PCL. In the future, it will be necessary to focus on the active metabolites of PCL, analyze its targets and signaling pathway network to address potential toxicity and side effects in clinical applications, and further expand the potential application of PCL in medicine.

补骨脂（Psoralea corylifolia L.，缩写PCL）为豆科（Fabaceae）补骨脂属一年生草本植物，其成熟果实作为名贵中药材，具有补益筋骨之功效。随着研究的不断深入，补骨脂的应用范畴已拓展至食品、农业、化妆品等多个领域，越南、印度、日本等国家均已开发出相关产品。目前已从补骨脂中鉴定出共计321种代谢物，涵盖香豆素类、黄酮类、杂萜类、苯并呋喃类以及二聚体类化合物。补骨脂及其相关产品已被证实具备多种药理活性，包括抗骨质疏松作用、类雌激素样效应、抗炎特性、神经保护功能、抗肿瘤活性以及白癜风治疗功效。上述药理活性的作用机制与免疫系统调控、氧化应激抑制以及细胞凋亡诱导密切相关。本文综述了补骨脂在民族植物学、植物化学、加工工艺、药理学及肝毒性领域的最新研究进展。此外，本研究采用文献计量分析法，系统剖析了补骨脂领域的研究热点与发展趋势——这也是既往补骨脂相关综述未曾覆盖的内容。未来的研究需聚焦于补骨脂的活性代谢物，解析其作用靶点与信号通路网络，以明确其临床应用中潜在的毒性与不良反应，并进一步拓展补骨脂在医药领域的应用潜力。