BRCA1 RING-domain variants with reported loss of function on the basis of in-vitro functional assays and/or (likely) clinically significant from multifactorial likelihood analysis.

*p.Met18Thr, p.Cys61Gly and p.Cys64Gly are also shown to have abrogated function using mouse embryonic stem cell assays [44], [49]. (No other variants listed in Table 3 were assayed using this method).*p.Met18Thr、p.Cys61Gly及p.Cys64Gly经小鼠胚胎干细胞实验检测，同样被证实存在功能失活[44]、[49]。（表3中所列的其余变异体均未采用该方法开展检测）。